{"id":370,"date":"2023-07-31T10:33:09","date_gmt":"2023-07-31T03:33:09","guid":{"rendered":"https:\/\/hoga.org.vn\/?p=370"},"modified":"2024-08-14T11:19:05","modified_gmt":"2024-08-14T04:19:05","slug":"y-hoc-chung-cu-va-ung-thu-buong-trung","status":"publish","type":"post","link":"https:\/\/hoga.org.vn\/?p=370","title":{"rendered":"Y H\u1ecdc Ch\u1ee9ng C\u1ee9 v\u00e0 Ung Th\u01b0 Bu\u1ed3ng Tr\u1ee9ng\u00a0"},"content":{"rendered":"\n

Y H\u1ecdc Ch\u1ee9ng C\u1ee9 v\u00e0 Ung Th\u01b0 Bu\u1ed3ng Tr\u1ee9ng <\/strong>l\u00e0 2 chuy\u00ean \u0111\u1ec1 l\u1edbn<\/strong>\u00a0g\u1ed3m 3 kh\u00f3a h\u1ecdc<\/strong>\u00a0n\u1eb1m trong khu\u00f4n kh\u1ed5 Chu\u1ed7i ch\u01b0\u01a1ng tr\u00ecnh \u0110\u00e0o t\u1ea1o Y khoa li\u00ean t\u1ee5c v\u1ec1 tr\u00ean n\u1ec1n t\u1ea3ng h\u1ecdc thu\u1eadt tr\u1ef1c tuy\u1ebfn v\u1ec1 ung th\u01b0 – OLAPro<\/strong>\u00a0\u0111\u01b0\u1ee3c ph\u1ed1i h\u1ee3p th\u1ef1c hi\u1ec7n b\u1edfi Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia v\u00e0 C\u00f4ng ty TNHH AstraZeneca Vi\u1ec7t Nam, v\u1edbi s\u1ef1 \u0111\u1ed3ng h\u00e0nh c\u1ee7a B\u1ec7nh vi\u1ec7n Ung b\u01b0\u1edbu TP.HCM, H\u1ed9i Ti\u1ebft ni\u1ec7u \u2013 Th\u1eadn h\u1ecdc TP.HCM v\u00e0 Li\u00ean chi H\u1ed9i Ph\u1ee5 s\u1ea3n TP.HCM.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

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C\u00e1c kh\u00f3a h\u1ecdc b\u1eaft \u0111\u1ea7u l\u00ean s\u00f3ng v\u00e0o ng\u00e0y: 20\/07\/2023 tr\u00ean n\u1ec1n t\u1ea3ng h\u1ecdc tr\u1ef1c tuy\u1ebfn. \u0110\u1ec3 tham gia kh\u00f3a h\u1ecdc v\u00e0 xem h\u01b0\u1edbng d\u1eabn \u0111\u0103ng k\u00fd, Qu\u00fd B\u00e1c S\u0129 vui l\u00f2ng truy c\u1eadp: www.nci-olapro<\/u><\/a>.vn\u00a0ho\u1eb7c qu\u00e9t m\u00e3 QR code trong \u1ea3nh b\u00ean d\u01b0\u1edbi.<\/p>\n\n\n\n

Qu\u00fd B\u00e1c S\u0129 s\u1ebd \u0111\u01b0\u1ee3c c\u1ea5p ch\u1ee9ng nh\u1eadn tham gia \u0110\u00e0o t\u1ea1o Y khoa li\u00ean t\u1ee5c b\u1edfi Vi\u1ec7n nghi\u00ean c\u1ee9u ph\u00f2ng ch\u1ed1ng ung th\u01b0 (Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia) khi: <\/p>\n\n\n\n

Tham gia\u00a0\u0111\u1ea7y \u0111\u1ee7 c\u00e1c ti\u1ebft h\u1ecdc (\u2265 80% th\u1eddi l\u01b0\u1ee3ng\u00a0m\u1ed7i kh\u00f3a h\u1ecdc – th\u1eddi l\u01b0\u1ee3ng h\u1ecdc th\u1ef1c t\u1ebf s\u1ebd \u0111\u01b0\u1ee3c ghi nh\u1eadn b\u1edfi n\u1ec1n t\u1ea3ng)\u00a0<\/p>\n\n\n\n

Ho\u00e0n th\u00e0nh \u0111\u00fang \u226580% c\u00e2u h\u1ecfi ki\u1ec3m tra<\/p>\n\n\n\n

Tham gia v\u00e0 ho\u00e0n th\u00e0nh kh\u00f3a h\u1ecdc, k\u1ec3 t\u1eeb ng\u00e0y 20\/07\/2023 \u00a0\u00a0<\/p>\n\n\n\n

V\u1ec1 n\u1ed9i dung chi bi\u1ebft kh\u00f3a h\u1ecdc v\u00e0 ban gi\u1ea3ng hu\u1ea5n, k\u00ednh m\u1eddi Qu\u00fd B\u00e1c S\u0129 tham kh\u1ea3o th\u00f4ng tin d\u01b0\u1edbi \u0111\u00e2y: <\/p>\n\n\n\n

Kh\u00f3a 1: Y h\u1ecdc Ch\u1ee9ng c\u1ee9 – C\u1eadp nh\u1eadt xu h\u01b0\u1edbng, di\u1ec5n gi\u1ea3i v\u00e0 \u1ee9ng d\u1ee5ng c\u00e1c th\u00f4ng s\u1ed1 ung th\u01b0 trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng<\/strong>\u00a0<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Trong th\u1eddi \u0111\u1ea1i c\u00e1c ki\u1ebfn th\u1ee9c y khoa \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt m\u1ed7i ng\u00e0y, c\u00e1c nh\u00e0 l\u00e2m s\u00e0ng lu\u00f4n ph\u1ea3i trong tr\u1ea1ng th\u00e1i s\u1eb5n s\u00e0ng c\u1eadp nh\u1eadt li\u00ean t\u1ee5c c\u00e1c b\u1eb1ng ch\u1ee9ng khoa h\u1ecdc m\u1edbi nh\u1ea5t tr\u00ean th\u1ebf gi\u1edbi trong ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb. Do v\u1eady c\u00e1c k\u1ef9 n\u0103ng li\u00ean quan <\/strong>Y h\u1ecdc Ch\u1ee9ng c\u1ee9 (Evidence Based Medicine) bao g\u1ed3m vi\u1ec7c \u0111\u00e1nh gi\u00e1 v\u00e0 di\u1ec5n gi\u1ea3i d\u1eef li\u1ec7u ng\u00e0y c\u00e0ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng y khoa \u1edf t\u1ea5t c\u1ea3 c\u00e1c l\u0129nh v\u1ef1c, \u0111\u1eb7c bi\u1ec7t l\u00e0 l\u0129nh v\u1ef1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0.  <\/p>\n\n\n\n

\u1ede kh\u00f3a h\u1ecdc \u0111\u1ea7u ti\u00ean, Qu\u00fd B\u00e1c S\u0129 s\u1ebd \u0111\u01b0\u1ee3c n\u00e2ng cao k\u1ef9 n\u0103ng v\u1ec1 Y h\u1ecdc Ch\u1ee9ng c\u1ee9 bao g\u1ed3m c\u1eadp nh\u1eadt c\u00e1c xu h\u01b0\u1edbng m\u1edbi nh\u1ea5t v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng trong ung th\u01b0, \u0111\u1ed3ng th\u1eddi c\u0169ng hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 c\u00e1c ngu\u1ed3n tra c\u1ee9u d\u1eef li\u1ec7u y h\u1ecdc ch\u1ee9ng c\u1ee9, c\u00e1ch di\u1ec5n gi\u1ea3i c\u00e1c th\u00f4ng s\u1ed1 \u0111a d\u1ea1ng trong nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng ung th\u01b0 (nghi\u00ean c\u1ee9u RCT, RWE v\u00e0 Meta-analysis*), t\u1eeb \u0111\u00f3 gi\u00fap ra quy\u1ebft \u0111\u1ecbnh l\u00e2m s\u00e0ng m\u1ed9t c\u00e1ch ph\u00f9 h\u1ee3p nh\u1ea5t, gi\u00fap b\u1ec7nh nh\u00e2n c\u00f3 c\u01a1 h\u1ed9i ti\u1ebfp c\u1eadn v\u1edbi c\u00e1c \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u01b0u v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng <\/p>\n\n\n\n

Kh\u00f3a 2: Ung th\u01b0 bu\u1ed3ng tr\u1ee9ng – t\u1eeb ch\u1ea9n \u0111o\u00e1n \u0111\u1ebfn ph\u1eabu thu\u1eadt<\/strong>\u00a0<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Ung th\u01b0 bu\u1ed3ng tr\u1ee9ng\u202fl\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh l\u00fd ung th\u01b0 ph\u1ed5 bi\u1ebfn \u1edf n\u1eef gi\u1edbi, sau ung th\u01b0 v\u00fa v\u00e0 ung th\u01b0 c\u1ed5 t\u1eed cung. Vi\u1ec7c ch\u1ea9n \u0111o\u00e1n \u0111\u00fang v\u00e0 ph\u00e2n lo\u1ea1i ph\u00f9 h\u1ee3p l\u00e0 b\u01b0\u1edbc ti\u1ebfp c\u1eadn \u0111\u1ea7u ti\u00ean trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p cho b\u1ec7nh nh\u00e2n. \u0110\u1ed1i v\u1edbi ung th\u01b0 bu\u1ed3ng tr\u1ee9ng, ph\u1eabu thu\u1eadt t\u1ed1i \u01b0u k\u1ebft h\u1ee3p v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb to\u00e0n th\u00e2n l\u00e0 n\u1ec1n t\u1ea3ng quan tr\u1ecdng gi\u00fap c\u1ea3i thi\u1ec7n s\u1ed1ng c\u00f2n cho b\u1ec7nh nh\u00e2n v\u1ec1 sau.<\/p>\n\n\n\n

V\u1edbi kh\u00f3a h\u1ecdc n\u00e0y, Qu\u00fd B\u00e1c S\u0129 s\u1ebd c\u00f3 c\u00e1i nh\u00ecn t\u1ed5ng quan v\u00e0 hi\u1ec3u h\u01a1n v\u1ec1 c\u00e1ch th\u1ee9c ti\u1ebfp c\u1eadn to\u00e0n di\u1ec7n \u0111\u1ed1i v\u1edbi b\u1ec7nh l\u00fd ung th\u01b0 bu\u1ed3ng tr\u1ee9ng, t\u1eeb ch\u1ea9n \u0111o\u00e1n \u2013 ph\u00e2n lo\u1ea1i ung th\u01b0 bu\u1ed3ng tr\u1ee9ng, ph\u00e2n t\u1ea7ng x\u1eed tr\u00ed kh\u1ed1i u tr\u01b0\u1edbc ph\u1eabu thu\u1eadt v\u00e0 t\u1ed5ng quan m\u00f4 th\u1ee9c \u0111i\u1ec1u tr\u1ecb. <\/p>\n\n\n\n

Kh\u00f3a 3: Ung th\u01b0 bu\u1ed3ng tr\u1ee9ng – \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa<\/strong>\u00a0<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Ung th\u01b0 bu\u1ed3ng tr\u1ee9ng c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi \u0111i\u1ec1u tr\u1ecb ban \u0111\u1ea7u bao g\u1ed3m ph\u1eabu thu\u1eadt v\u00e0 h\u00f3a tr\u1ecb, tuy nhi\u00ean b\u1ec7nh d\u1ec5 t\u00e1i ph\u00e1t trong 3 n\u0103m \u0111\u1ea7u ti\u00ean v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong c\u00f2n cao, do \u0111\u00f3 nhu c\u1ea7u t\u1ed1i \u01b0u h\u00f3a \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n ung th\u01b0 bu\u1ed3ng tr\u1ee9ng hi\u1ec7n nay l\u00e0 r\u1ea5t l\u1edbn.<\/p>\n\n\n\n

Trong k\u1ef7 nguy\u00ean c\u1ee7a y h\u1ecdc ch\u00ednh x\u00e1c, c\u00f9ng v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a c\u00e1c x\u00e9t nghi\u1ec7m gi\u1ea3i tr\u00ecnh t\u1ef1 gen th\u1ebf h\u1ec7 m\u1edbi (NGS), \u0111i\u1ec1u tr\u1ecb c\u00e1 th\u1ec3 h\u00f3a theo d\u1ea5u \u1ea5n sinh h\u1ecdc ph\u00e2n t\u1eed \u0111ang l\u00e0 h\u01b0\u1edbng ti\u1ebfp c\u1eadn \u0111\u1ed9t ph\u00e1 trong ung th\u01b0 bu\u1ed3ng tr\u1ee9ng, gi\u00fap k\u00e9o d\u00e0i l\u1ee3i \u00edch s\u1ed1ng c\u00f2n nhi\u1ec1u n\u0103m v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng cho b\u1ec7nh nh\u00e2n.  <\/p>\n\n\n\n

Kh\u00f3a h\u1ecdc t\u1eadp trung v\u00e0o v\u1ea5n \u0111\u1ec1 \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa v\u00e0 vai tr\u00f2 c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf PARP trong c\u00e1 th\u1ec3 h\u00f3a \u0111i\u1ec1u tr\u1ecb theo d\u1ea5u \u1ea5n HRD\/BRCA c\u0169ng nh\u01b0 c\u01a1 ch\u1ebf s\u1eeda sai DNA c\u1ee7a thu\u1ed1c n\u00e0y trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd ung th\u01b0. \u0110\u1eb7c bi\u1ec7t, n\u1ed9i dung kh\u00f3a h\u1ecdc c\u0169ng bao g\u1ed3m v\u1ea5n \u0111\u1ec1 qu\u1ea3n l\u00fd t\u00e1c d\u1ee5ng ph\u1ee5 c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb to\u00e0n th\u00e2n v\u00e0 n\u00e2ng cao th\u1ec3 ch\u1ea5t \u2013 dinh d\u01b0\u1ee1ng nh\u1eb1m gi\u00fap Qu\u00fd B\u00e1c S\u0129 \u0111\u1ec3 c\u00f3 th\u1ec3 \u0111\u1ed3ng h\u00e0nh v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng cho b\u1ec7nh nh\u00e2n.  <\/p>\n\n\n\n

Tr\u00e2n tr\u1ecdng c\u1ea3m \u01a1n v\u00e0 r\u1ea5t mong nh\u1eadn \u0111\u01b0\u1ee3c s\u1ef1 tham gia c\u1ee7a Qu\u00fd B\u00e1c S\u0129.  <\/p>\n\n\n\n

*Ch\u00fa th\u00edch:<\/p>\n\n\n\n

RCT: Randomized controlled trial- Th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng<\/p>\n\n\n\n

RWE: real world evidence- Nghi\u00ean c\u1ee9u \u0111\u1eddi th\u1ef1c<\/p>\n\n\n\n

Meta-analysis- ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p<\/p>\n\n\n\n

HRD: Homologous recombination deficiency- Suy gi\u1ea3m ch\u1ee9c n\u0103ng t\u00e1i t\u1ed5 h\u1ee3p t\u01b0\u01a1ng \u0111\u1ed3ng<\/p>\n\n\n\n

NGS: Next-generation sequencing- Gi\u1ea3i tr\u00ecnh t\u1ef1 gen th\u1ebf h\u1ec7 m\u1edbi<\/p>\n","protected":false},"excerpt":{"rendered":"

Y H\u1ecdc Ch\u1ee9ng C\u1ee9 v\u00e0 Ung Th\u01b0 Bu\u1ed3ng Tr\u1ee9ng l\u00e0 2 chuy\u00ean \u0111\u1ec1 l\u1edbn\u00a0g\u1ed3m 3 kh\u00f3a h\u1ecdc\u00a0n\u1eb1m trong khu\u00f4n kh\u1ed5 Chu\u1ed7i ch\u01b0\u01a1ng tr\u00ecnh \u0110\u00e0o t\u1ea1o…<\/p>\n","protected":false},"author":1,"featured_media":374,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-370","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-daotao"],"uagb_featured_image_src":{"full":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465.png",1191,990,false],"thumbnail":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465-150x150.png",150,150,true],"medium":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465-300x249.png",300,249,true],"medium_large":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465-768x638.png",768,638,true],"large":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465-1024x851.png",843,701,true],"1536x1536":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465.png",1191,990,false],"2048x2048":["https:\/\/hoga.org.vn\/wp-content\/uploads\/2023\/07\/Tong-quan-chuong-trinh-e1723609132465.png",1191,990,false]},"uagb_author_info":{"display_name":"Ban Bi\u00ean t\u1eadp","author_link":"https:\/\/hoga.org.vn\/?author=1"},"uagb_comment_info":0,"uagb_excerpt":"Y H\u1ecdc Ch\u1ee9ng C\u1ee9 v\u00e0 Ung Th\u01b0 Bu\u1ed3ng Tr\u1ee9ng l\u00e0 2 chuy\u00ean \u0111\u1ec1 l\u1edbn\u00a0g\u1ed3m 3 kh\u00f3a h\u1ecdc\u00a0n\u1eb1m trong khu\u00f4n kh\u1ed5 Chu\u1ed7i ch\u01b0\u01a1ng tr\u00ecnh \u0110\u00e0o t\u1ea1o…","_links":{"self":[{"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/posts\/370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=370"}],"version-history":[{"count":1,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/posts\/370\/revisions"}],"predecessor-version":[{"id":375,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/posts\/370\/revisions\/375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=\/wp\/v2\/media\/374"}],"wp:attachment":[{"href":"https:\/\/hoga.org.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hoga.org.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}